2 edition of Potential industrial carcinogens and mutagens found in the catalog.
Potential industrial carcinogens and mutagens
Includes bibliographical references and index.
|Series||Studies in environmental science -- 4|
|The Physical Object|
|Pagination||x, 534 p. :|
|Number of Pages||534|
This obligation applies only to chemicals that meet the criteria for classification as carcinogens or mutagens of categories 1A or 1B (according to CLP Regulation) or 1 or 2 (according to DSD). Substances that meet the classification criteria as 1 and 2A according to the International Agency for Research of Cancer (IARC), are also substances of. The edition lists 62 known human carcinogens and includes descriptions of the process for preparing the science-based report and the criteria used to list a substance as a carcinogen. IARC also produces science-based reports on substances .
Carcinogens are agents that can cause cancer. In industry, there are many potential exposures to carcinogens. Generally, workplace exposures are considered to be at higher levels than for public exposures. Safety data sheets (SDSs) should always contain an indication of carcinogenic potential. Carcinogens are addressed in specific OSHA. A mutagen is defined as any chemical that can cause changes in the DNA sequence of an organism. These changes are called mutations (hence mutation + genos (creator) = mutagen). Some mutagens are well-known: .
The steps from mutagen/ carcinogen to tumour involve mutagen/carcinogen activation by metabolism, reaction with DNA to give a DNA adduct and DNA replication of . In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level. As many mutations can cause cancer, mutagens are therefore also likely to be carcinogens, although not always necessarily mutagens have characteristic mutational .
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Print Book & E-Book. ISBNBook Edition: 1. 2-naphthylamine Abstr Acad acid acrolein acrylonitrile Agency for Research alkylating agents allyl allyl chloride animals Anon assay benzene benzidine Biphenyls bladder Cancer Inst Cancer Res carcinogenesis carcinogenic Carcinogenic Risk CARCINOGENS AND MUTAGENS carcinomas cells Chem chloroform chloroprene chromosome aberrations coli.
Potential Industrial Carcinogens and Mutagens | Lawrence Fishbein (Eds.) | download | B–OK. Download books for free. Find books. Search in this book series. Potential Industrial Carcinogens and Mutagens. Chapter 4 Tabular Summaries of Potential Industrial Carcinogens and Mutagens Pages Download PDF.
Chapter 27 Miscellaneous Potential Carcinogens and Mutagens Pages Download PDF. Chapter preview. Potential industrial carcinogens and mutagens.
Washington: Environmental Protection Agency, Office of Toxic Substances ; Springfield, Va.: For sale by the National Technical Information Service, (OCoLC) Material Type: Government publication, National government publication, Internet resource: Document Type: Book, Internet Resource.
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Mutagens and Carcinogens. A carcinogen is any agent that directly increases the incidence of cancer. Most, but not all carcinogens are mutagens. Carcinogens that do not directly damage DNA include substances that accelerate cell division, thereby leaving less opportunity for cell to repair induced mutations, or errors in replication.
Many chemical carcinogens are reactive electrophiles per Se, e.g., alkylating agent, acylating en, and other electrophiles 2 ’ Despite the diversity in chemical structures of known carcinogens and mutagens, such as alkylating agents, N-nitrosamines and N-thtrosamides, rutro aryl- and furan derivatives, aromatic and heterocyclic amines and azo dyes.
Carcinogens cause cancerous tumors with a characteristically crablike appearance. Mutagens, teratogens and carcinogens are similar in that each causes some form of mutation. Congenital malformations can be caused by mutations, which may occur in the parent germ cell (sperm or ovum).
Mutagenicity and carcinogenicity are clearly correlated. One study showed that of known carcinogens (approximately 90 percent) are also mutagens. The somatic mutation theory of cancer holds that these agents cause cancer by inducing the mutation of somatic cells.
Thus, understanding mutagenesis is of great relevance to our : Anthony Jf Griffiths, Jeffrey H Miller, David T Suzuki, Richard C Lewontin, William M Gelbart.
Carcinogens; the Other Contains 10Percent Distribution and Number of Animals in a Typical Bioassay Study of Carcinogens. Guidelines for Bioassay in SmalI Rodents Some Organizations That Have Considered and Endorsed Animal Tests as Predictors of Human Risk From Chemical Carcinogens l29 Advantages and Disadvantages of Case.
Potential Industrial Carcinogens and Mutagens. Borrow eBooks, audiobooks, and videos from thousands of public libraries worldwide. Other topics include mutagenesis and mutagen-formation inhibitors, contemporary mutagen detection methods, the fate of ingested mutagens, and risk assessments for mutagens as human carcinogens.
The book emphasizes cooked-food mutagens, especially the heterocyclic amines, because of their potential as human carcinogens. This chapter outlines the potential industrial carcinogens and mutagens. The industrial carcinogens discussed are classified into five major classes—(1) alkylating and acylating agents and peroxides, (2) halogen derivatives, (3) nitrogen derivatives, (4) hydrocarbon and oxygen derivatives, and (5) phosphorus derivatives and miscellaneous potential industrial.
Several large-scale trials, carried out to test the usefulness of these assays in detecting potential carcinogens and mutagens (Purchase et al., ; McMahon et al., ; Bartsch et al., ; de Serres & Ashby, ), have shown that bacterial mutation assays are very good at picking out chemicals known to cause cancer.
Further volumes in this series will be published in the book series Developments in Environmental Science. EC (the Carcinogens and Mutagens Directive – CMD). The second proposal (hereafter referred to as the ‘current proposal’) complements a first one of 13 May1 by addressing another batch of substances for which additional analysis had still to be conducted.
(For more details, see ‘The proposed changes and their potential impact File Size: KB. Call: am to pm, Monday to Friday. Use our (01) number to avoid possible additional charges from your mobile operator.Environmental Carcinogens and Mutagens a mutation in a cancer gene may result in enhanced growth potential, and ultimately in book about exposures to chemical carcinogens Author: Edward L Loechler.NATURALLY OCCURRING MUTAGENS and CARCINOGENS FOUND in FOODS and BEVERAGES (continued from page 3)ETHYL ACRYLATE (pineapple)—rodent carcinogen ETHYL BENZENE (coffee)—rodent carcinogen ETHYL CARBAMATE (bread, rolls, red wine)—mutagen and rodent carcinogen FURAN AND FURAN DERIVATIVES(bread, onions.